Ecological & Evolutionary Epigenomics
Wu et al. 2020 (click image to view full size)
Wu et al. 2020. PLoS Pathogens demonstrating genomic patterns of differentially methylated genes vs. differentially expressed genes.
Wu et al. 2020 (click image to view full size)

Ecological & Evolutionary Epigenomics

Epigenetic mechanisms are widespread throughout the tree of life, but its components and how each component interact with each other vary greatly across different taxa. For example, genomic patterns of DNA methylation in invertebrate animals differ greatly from those of vertebrates. We investigate variation of epigenetic regulation across the genome and among species, and functional consequences of such variation. A major focus of our current research is to investigate how DNA methylation changes in response to system-wide perturbation (such as disease or ecological changes), and to understand the implications of such changes at the phenotypic level.

 Researchers

Professor
An evolutionary biologist who uses genomic and epigenomic approaches.
Graduate Student Researcher
Evolution and origin of enhancers in the human genome.
Graduate Student Researcher
Genomic scientist studying evolution of human brains and many other organisms.
Graduate Student Researcher
Bioinformatics/computational biologist studying regulatory evolution.